{"database": "canada-spends", "table": "cihr_grants", "rows": [["170057", "Neurobiological basis of the effects of methamphetamine (Crystal  Meth):  a behavioural and electrophysiological study.", "Dumont  Eric C", "Dumont, Eric C", "Queen's University (Kingston, Ontario)", "Ontario", "Canada", "200810", "20750.0", "Catalyst Grant: Prevention and Treatment of Illicit Substance Use", "Operating Grants", "Biomedical", "Neurosciences, Mental Health and Addiction", "Bed Nucleus Of The Stria Terminalis; Brain Slices; Methamphetamine (Crystal Meth); Patch-Clamp; Self-Administration; Synaptic Transmission", "In spite of intense efforts in research, as well as clinical and field \ninterventions to prevent and treat drug addiction, this health \nproblem is still devastating and worse, is still growing. In \nparticular, methamphetamine (Crystal Meth) is relatively easy \nand cheap to synthesize: the recipe is available on the internet \nand ingredients can be purchased over the counter at the local \npharmacy. Most current therapies provide short-term solutions \nto help detoxification and support abstinence. However, the \nmain problem in treating or preventing addiction is the long \nlasting, even permanent, neuronal alterations produces by drugs \nof abuse. These long-lasting alterations underlie the \naggravating properties of several risk factors and the difficulty of \nremaining abstinent after detoxification.\n\tMy research program investigates the neuronal basis of the \nlong term and somehow permanent neuronal modifications \ninduced by drugs of abuse. This particular research projects will \ndetermine the effects of Crystal Meth on synaptic transmission \ncombining behavioural testing of methamphetamine self-\nadministration in rodents with patch-clamp recordings in brain \nslices. The long term objective is to help in developing therapies \naimed at reversing these neuronal modifications and hope to \npermanently occlude susceptibility to develop addiction or to \nrelapse albeit sincere efforts to refrain.", "1 yr 0 mth", "https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170057&lang=en"]], "columns": ["external_id", "title", "project_lead_name", "co_researchers", "institution", "province", "country", "competition_year", "award_amount", "program", "program_type", "theme", "research_subject", "keywords", "abstract", "duration", "source_url"], "primary_keys": ["external_id"], "primary_key_values": ["170057"], "units": {}, "query_ms": 3.500553997582756}