{"database": "canada-spends", "table": "cihr_grants", "rows": [["170643", "Sleep and circadian rhythms in the middle years of life", "Carrier  Julie", "Carrier, Julie", "CIUSSS du Nord-de-l'Ile-de Montréal - Hôpital Sacré Coeur", "Québec", "Canada", "200809", "472764.0", "Operating Grant", "Operating Grants", "Clinical", "Aging", "Aging; Brain Imaging; Circadian Rhythms; Electrophysiology; Sleep; Vigilance", "The current overwhelming evidence that aging is associated with a significant increase in sleep-wake cycle complaints has\nimportant individual, social and economical consequences. Multiple factors, including health problems, side effects of\nmedications and specific sleep disorders, account for this age-related increase in sleep difficulties. However, critical changes\nin the sleep-wake cycle are also observed in optimal aging, i.e., when people do not suffer from medical, psychiatric or\nspecific sleep disorders. These age-related changes occur as early as the middle years of life. Between the ages of 20 and\n60, increasing age is associated with less time asleep, more awakenings during sleep, less deep sleep, and more lighter\nstages of sleep. With increasing age, sleep is also more vulnerable to challenges such as jet-lag or shift-work. The long term\ngoal of our research program is to understand the mechanisms that underlie age-related modifications of the sleep-wake\ncycle. In this proposal, we will use innovative brain imaging techniques to evaluate if age-related changes in brain\nmorphology and activity may explain age-related changes in the sleep-wake cycle. The sleep of young (20-39 y.o.) and\nmiddle-aged subjects (40-60 y.o.) will studied under habitual and sleep deprivation conditions. This research should provide\nimportant answers on how aging impacts sleep oscillations in their role to protect sleep and how age-related changes in the\nbrain during sleep oscillations may underlie changes in vigilance and cognition. The long-term goal of our research program\nis to develop preventive and therapeutic strategies for the older population based on the mechanisms underlying age-related\nchanges of the sleep-wake cycle.", "4 yrs 0 mth", "https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170643&lang=en"]], "columns": ["external_id", "title", "project_lead_name", "co_researchers", "institution", "province", "country", "competition_year", "award_amount", "program", "program_type", "theme", "research_subject", "keywords", "abstract", "duration", "source_url"], "primary_keys": ["external_id"], "primary_key_values": ["170643"], "units": {}, "query_ms": 0.5173319950699806}